Summary
Background The continuous outbreak of COVID-19 poses a devastating threat to the global public health, and there’s no special therapeutic drugs. This paper is to explore the effect of high fiber whey short peptide enteral nutrition on the prognosis of patients with COVID-19, to find ways to prevent patients from progressing to severe illness, and to reduce the harm of epidemic situation to human beings.
Methods The course of fighting against COVID-19 in our hospital for 49 days was reviewed. Three nutritional interventions including five-step nutrition treatment, 46early intervention of whole protein, and high fiber whey short peptide intervention were conducted consecutively.The effect of high fiber whey short peptide on nutrition, immune function and prognosis of patients with COVID-19 was compared with that of whole protein intervention.
Results High fiber whey short peptide group when compared with whey protein group, can significantly improve prealbumin in patients with covid-19, improve the negative nitrogen balance of patients, and reduce the average period of turning negative by 39.06%.
Conclusion High fiber whey short peptide can significantly improve the recovery speed of patients with covid-19.
Funding none
Competing Interest Statement
The authors have declared no competing interest.
Clinical Trial
Clinical trial ID:HEC-KYJJ2020-015-01.This paper is a retrospective study,all procedures are carried out in accordance with the Helsinki Declaration and relevant Chinese policies.
Funding Statement
During the epidemic, according to local laws and regulations, Zhang Tianping, the author of this article, donated high fiber whey nano-short peptides through the Yichang Red Cross. Zhang Tianping has no interest relationship with Yichang Central people's Hospital and related personnel.There is no source of funding.Data collection, analysis,or interpretation,trial design, Any aspect related to the research shall be completed by the corresponding authors and their own expenses shall be borne.
Author Declarations
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
This paper is a retrospective study.From January 29, 2020 to March 17, 2020,According to the clinical medical standard, Yichang Central People's Hospital implemented the enteral nutrition intervention for the inpatients of covid-19,including whey protein enteral nutrition and nano short peptide enteral nutrition intervention.There are differences between the two kinds of interventions in clinical practice.With the approval of the ethics committee of Yichang Central People's Hospital,Dr.Zelin Zhang, Yang Lin, etc and others were agreed to carry out a retrospective study on these patients with covid-19 nutritional intervention.Clinical trial ID:HEC-KYJJ2020-015-01.All of the procedures were performed in accordance with the Declaration of Helsinki and relevant policies in China.
All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes
Data Availability
All raw data are from Yichang Central People's Hospital, Hubei Province, China.