Abstract
A retrospective analysis was performed.39 (50.6%) of 77 suspected cases were comfirmed, 4 (5.2%) of them had viral coinfection. Compared with non-2019-nCoV group(n=33),2019-nCoV confirmed group (n=39) had fewer fever and symptoms of acute respiratory infection (ARI), more asymptomatic and more family cluster infections. While computed tomography (CT) had more positive findings of viral pneumonia. Age and gender were insignificant. PCT (0.05[0.029-0.076] vs 0.103[0.053-0.21];P<.001) of 2019-nCoV alone group (n=35) was significantly reduced. While compared with coinfection group (n=4), PCT (0.05[0.029–0.076] vs 0.144[0.109–2.26];P=.003) was also statistically reduced. The area under curve (AUC) of receiver operating characteristic (ROC) of overall model is 0.817 ([95%CI] [0.719-0.916];P<.001). The AUC of PCT is 0.792 ([0.688-0.896];P<.001). The cut-off value is 0.1 ng/mL. Asymptoms or mild symptoms, positive CT findings and family cluster infection are the main clinical features of pediatric 2019-nCoV infection. With moderate efficacy, PCT can provide an important basis for differentiating 2019-nCoV alone and other viral infection or viral coinfection.
Competing Interest Statement
The authors have declared no competing interest.
Funding Statement
Did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Author Declarations
All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.
Yes
All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes
Footnotes
Compliance with Ethical Statements
Conflict of Interest: All authors declare that they have no conflict of interest.
Funding: There is no funding source.
Ethical approval: This article does not contain any studies with human participants or animals performed by any of the authors. This investigation was approved by the Ethics Committee of The Third People’s Hospital of Shenzhen (2020–123).
- Abbreviations
- 2019-nCoV
- 2019 novel coronavirus
- AUC
- area under curve
- ARI
- acute respiratory infection
- CI
- confidence interval
- CAP
- community acquired pneumonia
- CT
- computed tomography
- hs-CRP
- high sensitivity C-reactive protein
- Hb
- Hemoglobin
- INFA, B
- influenza A, B
- IQR
- interquartile range
- LC
- lymphocyte count
- L%
- percentage of lymphocyte
- MP
- mycoplasma pneumoniae
- NPV
- negative predictive value
- N%
- percentage of neutrophil
- NC
- neutrophil count
- OR
- odds ratio
- PPV
- positive predictive value
- PLT
- platelet
- PCT
- procalcitonin
- ROC
- receiver operating characteristic curve
- RT-PCR
- real-time reverse transcriptase polymerase chain reaction
- RSV
- respiratory syncytial virus
- SD
- standard deviation
- SE
- standard error
- WBC
- white blood cell
Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, University of Washington, and Vrije Universiteit Amsterdam.
Subject Area
Reviews and Context
0
Comment
0
TRIP Peer Reviews
0
Community Reviews
0
Automated Services
0
Blogs/Media
Author Videos